Selected publications:
Application of Single-cell rna sequencing methods to develop b cell targeted treatments for autoimmunity
Nicholas CA, Smith MJ. Application of single-cell RNA sequencing methods to develop B cell targeted treatments for autoimmunity. Front Immunol. 2023 Jul 14;14:1103690. doi: 10.3389/fimmu.2023.1103690. PMID: 37520578; PMCID: PMC10382068.
identification of an anergic bnd cell-derived activated b cell population (bnd2) in young-onset type 1 diabetes patients
Stensland ZC, Magera CA, Broncucia H, Gomez BD, Rios-Guzman NM, Wells KL, Nicholas CA, Rihanek M, Hunter MJ, Toole KP, Gottlieb PA, Smith MJ. Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients. J Exp Med. 2023 Aug 7;220(8):e20221604. doi: 10.1084/jem.20221604. Epub 2023 May 15. PMID: 37184563; PMCID: PMC10192302.
Peripheral immunophenotyping of aitd subjects reveals alterations in immune cells in pediatric vs adult-onset aitd
Stensland ZC, Coleman BM, Rihanek M, Baxter RM, Gottlieb PA, Hsieh EWY, Sarapura VD, Simmons KM, Cambier JC, Smith MJ. Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD. iScience. 2021 Dec 13;25(1):103626. doi: 10.1016/j.isci.2021.103626. PMID: 35005561; PMCID: PMC8718984.
Enrichment and Detection of Antigen-Binding B Cells for Mass Cytometry
Stensland, Zachary C, and Mia J Smith. “Enrichment and Detection of Antigen-Binding B Cells for Mass Cytometry.” Magnetochemistry (Basel, Switzerland) vol. 7,7 (2021): 92. doi:10.3390/magnetochemistry7070092
Therapeutic Targeting of Autoreactive B cells: Why, How, and When?
Stensland, Zachary C et al. “Therapeutic Targeting of Autoreactive B Cells: Why, How, and When?.” Biomedicines vol. 9,1 83. 16 Jan. 2021, doi:10.3390/biomedicines9010083
endotypes in t1d: b lymphocytes and early onset
Smith MJ, Cambier JC, Gottlieb PA. Endotypes in T1D: B lymphocytes and early onset. Curr Opin Endocrinol Diabetes Obes. 2020 Aug;27(4):225-230. doi: 10.1097/MED.0000000000000547.
Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity.
Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. JCI Insight. 2019 Feb 7;4(3). pii: 123384. doi: 10.1172/jci.insight.123384.
Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice.
Smith MJ, Hinman RM, Getahun A, Kim S, Packard TA, Cambier JC. Diabetologia. 2018 Dec;61(12):2621-2632. doi: 10.1007/s00125-018-4730-z. Epub 2018 Sep 25.
Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation.
Takeda K1, Webb TL2, Ning F3, Shiraishi Y3, Regan DP2, Chow L2, Smith MJ2, Ashino S3, Guth AM2, Hopkins S2, Gelfand EW3, Dow S2. J Immunol. 2018 Feb 15;200(4):1261-1269. doi: 10.4049/jimmunol.1700562. Epub 2018 Jan 19.
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles.
Smith MJ, Rihanek M, Wasserfall C, Mathews CE, Atkinson MA, Gottlieb PA, Cambier JC. Diabetes. 2018 Apr;67(4):697-703. doi: 10.2337/db17-0937. Epub 2018 Jan 17.
Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.
Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. J Autoimmun. 2018 May;89:82-89. doi: 10.1016/j.jaut.2017.12.001. Epub 2017 Dec 9.
B cells in type 1 diabetes mellitus and diabetic kidney disease.
Smith MJ, Simmons KM, Cambier JC. Nat Rev Nephrol. 2017 Oct 17;13(11):712-720. doi: 10.1038/nrneph.2017.138. Review.
Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function.
Smith MJ, Packard TA, O'Neill SK, Hinman RM, Rihanek M, Gottlieb PA, Cambier JC. J Vis Exp. 2017 Feb 16;(120). doi: 10.3791/55382.
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. JCI Insight. 2016 Dec 8;1(20):e88242. doi: 10.1172/jci.insight.88242.
B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes.
Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. J Clin Med. 2016 Nov 8;5(11). pii: E98.
Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.
Smith MJ, Packard TA, O'Neill SK, Henry Dunand CJ, Huang M, Fitzgerald-Miller L, Stowell D, Hinman RM, Wilson PC, Gottlieb PA, Cambier JC. Diabetes. 2015 May;64(5):1703-12. doi: 10.2337/db13-1798. Epub 2014 Dec 18.
B cells and type 1 diabetes ...in mice and men.
Hinman RM, Smith MJ, Cambier JC. Immunol Lett. 2014 Aug;160(2):128-32. doi: 10.1016/j.imlet.2014.01.010. Epub 2014 Jan 25. Review.
Anti-CD79 antibody induces B cell anergy that protects against autoimmunity.
Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. J Immunol. 2014 Feb 15;192(4):1641-50. doi: 10.4049/jimmunol.1302672. Epub 2014 Jan 17.
Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection.
Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC. J Immunol. 2012 Sep 15;189(6):2965-74. doi: 10.4049/jimmunol.1201407. Epub 2012 Aug 17.
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.
O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC. Immunity. 2011 Nov 23;35(5):746-56. doi: 10.1016/j.immuni.2011.10.011. Epub 2011 Nov 9.